Last update
8/23/2025
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 11 Researches
8
USERS' SCORE
Good
Based on 10 Reviews
8.2
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B1 (as thiamin HCl)
500 mg
41,667%
Top Medical Research Studies
9
We explored the fascinating world of cyclotides, which are plant-derived peptides that can either support or suppress immune responses. Our focus was on a modified version of kalata B1, known as [T20K], which showed encouraging results in treating multiple sclerosis in preclinical studies.
Administering [T20K] led to significantly lower cytokine levels, minimal demyelination, and reduced inflammation in mice. In comparison to standard immunosuppressive drugs, [T20K] also showed lower mortality and morbidity rates. While the research is promising, more studies are needed to confirm these findings in humans.
Administering [T20K] led to significantly lower cytokine levels, minimal demyelination, and reduced inflammation in mice. In comparison to standard immunosuppressive drugs, [T20K] also showed lower mortality and morbidity rates. While the research is promising, more studies are needed to confirm these findings in humans.
Read More
9
We examined how ascorbic acid influences autoimmune disorders, particularly rheumatoid arthritis (RA). By injecting mice with ascorbic acid, we observed reduced disease severity and delayed onset compared to those receiving a similar saline solution.
Our research showed that ascorbic acid significantly lowered the levels of harmful autoantibodies and limited the development of autoreactive plasma cells. Additionally, it affected B cell differentiation and even promoted cell death within B cells, specifically by inhibiting certain signaling pathways.
In summary, ascorbic acid demonstrates promise as a potential treatment for managing RA symptoms and autoantibody production.
Our research showed that ascorbic acid significantly lowered the levels of harmful autoantibodies and limited the development of autoreactive plasma cells. Additionally, it affected B cell differentiation and even promoted cell death within B cells, specifically by inhibiting certain signaling pathways.
In summary, ascorbic acid demonstrates promise as a potential treatment for managing RA symptoms and autoantibody production.
Read More
8
We examined the role of the kinin B1 receptor in managing brain barrier issues linked to autoimmune disorders. Using a rat model of multiple sclerosis, we blocked this receptor and saw notable improvements.
The treatment reduced symptoms, recovered key proteins that strengthen the blood-brain barrier, and lessened inflammation in the brain. These findings highlight how targeting the B1 receptor could play a crucial role in protecting against the inflammation seen in autoimmune conditions.
The treatment reduced symptoms, recovered key proteins that strengthen the blood-brain barrier, and lessened inflammation in the brain. These findings highlight how targeting the B1 receptor could play a crucial role in protecting against the inflammation seen in autoimmune conditions.
Read More
Most Useful Reviews
9
Nerve damage relief
8 people found this helpful
Solgar Thiamin 500mg was prescribed for my husband by a neurologist after he developed "drop foot" post knee replacement. It has significantly aided his nerve damage and alleviated most symptoms. He was advised that even a year post-surgery, improvement could still be seen. I have consistently achieved positive results with Solgar products, making this our choice.
Read More
7.5
Morning fatigue relief
8 people found this helpful
I purchased this for added support for autoimmune thyroiditis. With regular use, it helps combat that "woke up tired" feeling. One tablet per day suffices. Thiamine isn't available separately in pharmacies, only in small doses combined with others, but this offers 100 tablets at an affordable price from a reputable manufacturer (Solgar).
Read More
7.5
Anxiety management
6 people found this helpful
I began taking B1 for anxiety disorder after reading another review about its efficacy. I've been using 1000-1500mg daily in divided doses for about six weeks, and it truly helps without sedation or side effects. I also use other mild supplements that require time but find B1 acts quickly, taking the edge off without overwhelming drowsiness. This formula reduces the number of pills I need. Fantastic!
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 11 Researches
8
- All Researches
9
We explored the fascinating world of cyclotides, which are plant-derived peptides that can either support or suppress immune responses. Our focus was on a modified version of kalata B1, known as [T20K], which showed encouraging results in treating multiple sclerosis in preclinical studies.
Administering [T20K] led to significantly lower cytokine levels, minimal demyelination, and reduced inflammation in mice. In comparison to standard immunosuppressive drugs, [T20K] also showed lower mortality and morbidity rates. While the research is promising, more studies are needed to confirm these findings in humans.
Administering [T20K] led to significantly lower cytokine levels, minimal demyelination, and reduced inflammation in mice. In comparison to standard immunosuppressive drugs, [T20K] also showed lower mortality and morbidity rates. While the research is promising, more studies are needed to confirm these findings in humans.
Read More
9
We examined how ascorbic acid influences autoimmune disorders, particularly rheumatoid arthritis (RA). By injecting mice with ascorbic acid, we observed reduced disease severity and delayed onset compared to those receiving a similar saline solution.
Our research showed that ascorbic acid significantly lowered the levels of harmful autoantibodies and limited the development of autoreactive plasma cells. Additionally, it affected B cell differentiation and even promoted cell death within B cells, specifically by inhibiting certain signaling pathways.
In summary, ascorbic acid demonstrates promise as a potential treatment for managing RA symptoms and autoantibody production.
Our research showed that ascorbic acid significantly lowered the levels of harmful autoantibodies and limited the development of autoreactive plasma cells. Additionally, it affected B cell differentiation and even promoted cell death within B cells, specifically by inhibiting certain signaling pathways.
In summary, ascorbic acid demonstrates promise as a potential treatment for managing RA symptoms and autoantibody production.
Read More
8
We assessed how a two-week reactive balance training program could help individuals with multiple sclerosis (PwMS) avoid falls. This study involved six training sessions where participants faced various balance challenges.
Results showed promising outcomes: PwMS experienced immediate and lasting improvements in their reactive stepping abilities, especially with quicker response times. Although this was a small, non-randomized trial, it suggests that this training approach is feasible and may effectively enhance balance in PwMS.
However, further research is needed to confirm these findings and understand its long-term benefits.
Results showed promising outcomes: PwMS experienced immediate and lasting improvements in their reactive stepping abilities, especially with quicker response times. Although this was a small, non-randomized trial, it suggests that this training approach is feasible and may effectively enhance balance in PwMS.
However, further research is needed to confirm these findings and understand its long-term benefits.
Read More
8
Podocyte exosomes affect endothelial injury
We investigated how exosomes from renal podocytes affect glomerular endothelial cell injury in lupus nephritis (LN). Our results showed that these exosomes, loaded with high mobility group protein B1 (HMGB1), were released in patients and animal models of LN. By using specific inhibitors, we found that blocking exosome release improved endothelial cell function. We also discovered that manipulating the levels of TRIM27—affected by HMGB1—significantly changed the damage to these cells. Overall, our findings suggest that targeting podocyte-derived exosomes could be a potential strategy to mitigate endothelial injury related to LN.
Read More
8
We explored a unique case of a 65-year-old man with a history of idiopathic thrombocytopenic purpura (ITP) who developed Guillain-Barre and acute transverse myelitis overlap syndrome after contracting COVID-19.
Upon noticing symptoms like limb weakness and facial paralysis, he received immediate treatment including intravenous immune globulin and steroids. Remarkably, he made a significant recovery within eight weeks and was able to resume normal activities.
This case highlights the potential complications of COVID-19 and the importance of prompt intervention for patients with underlying immune conditions.
Upon noticing symptoms like limb weakness and facial paralysis, he received immediate treatment including intravenous immune globulin and steroids. Remarkably, he made a significant recovery within eight weeks and was able to resume normal activities.
This case highlights the potential complications of COVID-19 and the importance of prompt intervention for patients with underlying immune conditions.
Read More
User Reviews
USERS' SCORE
Good
Based on 10 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Nerve damage relief
8 people found this helpful
Solgar Thiamin 500mg was prescribed for my husband by a neurologist after he developed "drop foot" post knee replacement. It has significantly aided his nerve damage and alleviated most symptoms. He was advised that even a year post-surgery, improvement could still be seen. I have consistently achieved positive results with Solgar products, making this our choice.
Read More
7.5
Morning fatigue relief
8 people found this helpful
I purchased this for added support for autoimmune thyroiditis. With regular use, it helps combat that "woke up tired" feeling. One tablet per day suffices. Thiamine isn't available separately in pharmacies, only in small doses combined with others, but this offers 100 tablets at an affordable price from a reputable manufacturer (Solgar).
Read More
7.5
Anxiety management
6 people found this helpful
I began taking B1 for anxiety disorder after reading another review about its efficacy. I've been using 1000-1500mg daily in divided doses for about six weeks, and it truly helps without sedation or side effects. I also use other mild supplements that require time but find B1 acts quickly, taking the edge off without overwhelming drowsiness. This formula reduces the number of pills I need. Fantastic!
Read More
7.5
Calmer and energetic
4 people found this helpful
Following illness, my nervous system was severely compromised along with chronic fatigue and some anxiety. The doctor prescribed B1 and magnesium, and I trusted Solgar. Combined, I felt effects appeared in about a week. I have become calmer and more energetic.
Read More
7.5
Heartbeat improvement
3 people found this helpful
I ordered this thiamine due to heartbeat issues. After ten days of taking one tablet daily, my condition significantly improved. It's essential to take it separately from other vitamins for the best results.
Read More
Frequently Asked Questions
7.5
Calmer and energetic
4 people found this helpful
Following illness, my nervous system was severely compromised along with chronic fatigue and some anxiety. The doctor prescribed B1 and magnesium, and I trusted Solgar. Combined, I felt effects appeared in about a week. I have become calmer and more energetic.
7.5
Heartbeat improvement
3 people found this helpful
I ordered this thiamine due to heartbeat issues. After ten days of taking one tablet daily, my condition significantly improved. It's essential to take it separately from other vitamins for the best results.
7.5
Reduced Parkinson's symptoms
3 people found this helpful
I'm delighted with the fast delivery. The packaging is excellent, with tablets stored in a dark glass bottle that protects them from sunlight, reflecting the manufacturer’s commitment to quality. I find it easy to swallow the tablets, which I take alongside levadopa/carbidopa for Parkinson's disease. I anticipate noticing results after six months of consistent use and will reorder since I've already experienced a reduction in symptoms like tremor.
9
Nerve damage relief
8 people found this helpful
Solgar Thiamin 500mg was prescribed for my husband by a neurologist after he developed "drop foot" post knee replacement. It has significantly aided his nerve damage and alleviated most symptoms. He was advised that even a year post-surgery, improvement could still be seen. I have consistently achieved positive results with Solgar products, making this our choice.
7.5
Morning fatigue relief
8 people found this helpful
I purchased this for added support for autoimmune thyroiditis. With regular use, it helps combat that "woke up tired" feeling. One tablet per day suffices. Thiamine isn't available separately in pharmacies, only in small doses combined with others, but this offers 100 tablets at an affordable price from a reputable manufacturer (Solgar).
7.5
Anxiety management
6 people found this helpful
I began taking B1 for anxiety disorder after reading another review about its efficacy. I've been using 1000-1500mg daily in divided doses for about six weeks, and it truly helps without sedation or side effects. I also use other mild supplements that require time but find B1 acts quickly, taking the edge off without overwhelming drowsiness. This formula reduces the number of pills I need. Fantastic!
6
Chronic fatigue improvement
1 people found this helpful
I noticed some improvement from high-dose thiamine for chronic fatigue. After several orders, I switched to allithiamine.
9
We explored the fascinating world of cyclotides, which are plant-derived peptides that can either support or suppress immune responses. Our focus was on a modified version of kalata B1, known as [T20K], which showed encouraging results in treating multiple sclerosis in preclinical studies.
Administering [T20K] led to significantly lower cytokine levels, minimal demyelination, and reduced inflammation in mice. In comparison to standard immunosuppressive drugs, [T20K] also showed lower mortality and morbidity rates. While the research is promising, more studies are needed to confirm these findings in humans.
Administering [T20K] led to significantly lower cytokine levels, minimal demyelination, and reduced inflammation in mice. In comparison to standard immunosuppressive drugs, [T20K] also showed lower mortality and morbidity rates. While the research is promising, more studies are needed to confirm these findings in humans.
9
We examined how ascorbic acid influences autoimmune disorders, particularly rheumatoid arthritis (RA). By injecting mice with ascorbic acid, we observed reduced disease severity and delayed onset compared to those receiving a similar saline solution.
Our research showed that ascorbic acid significantly lowered the levels of harmful autoantibodies and limited the development of autoreactive plasma cells. Additionally, it affected B cell differentiation and even promoted cell death within B cells, specifically by inhibiting certain signaling pathways.
In summary, ascorbic acid demonstrates promise as a potential treatment for managing RA symptoms and autoantibody production.
Our research showed that ascorbic acid significantly lowered the levels of harmful autoantibodies and limited the development of autoreactive plasma cells. Additionally, it affected B cell differentiation and even promoted cell death within B cells, specifically by inhibiting certain signaling pathways.
In summary, ascorbic acid demonstrates promise as a potential treatment for managing RA symptoms and autoantibody production.
References
- Mishra R, Agarwal P, Sharma A, Mittal M, Gulati P, et al. Plant-derived Cyclotides in Immunomodulation and their Therapeutic Potential. Protein Pept Lett. 2025. 10.2174/0109298665364479250214101422
- Peterson DS, Monaghan AS, Hooyman A, Trevino JL, Kratz K. Feasibility and preliminary effectiveness of a 2-week in-place reactive balance training program in people with multiple sclerosis. Mult Scler Relat Disord. 2025;95:106346. 10.1016/j.msard.2025.106346
- Liu J, Zhao T, Cui H, Tian Y, Miao X, et al. HMGB1 Encapsulated in Podocyte-Derived Exosomes Plays a Central Role in Glomerular Endothelial Cell Injury in Lupus Nephritis by Regulating TRIM27 Expression. Lab Invest. 2025;105:104096. 10.1016/j.labinv.2025.104096
- Li Q, Duan D, Wang X, Sun M, Liu Y, et al. [High mobility group protein B1(HMGB1) promotes myeloid dendritic cell maturation and increases Th17 cell/Treg cell ratio in patients with immune primary thrombocytopenia]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2025;41:45.
- Chen R, Wang L, Wang B, Song X, Liu X. Concurrent Guillain-Barre/acute transverse myelitis overlap syndrome after COVID-19 infection in a patient with ITP: A case report. Medicine (Baltimore). 2024;103:e40346. 10.1097/MD.0000000000040346
- Sulkowski G, Dąbrowska-Bouta B, Frontczak-Baniewicz M, Strużyńska L. Involvement of the Kinin B1 Receptor in Increased Permeability of Cerebral Microvessels in Rats Subjected to Autoimmune Encephalomyelitis. Cells. 2024;13. 10.3390/cells13191641
- Bhoj PS, Nocito C, Togre NS, Winfield M, Lubinsky C, et al. Tissue Kallikrein-1 Suppresses Type I Interferon Responses and Reduces Depressive-Like Behavior in the MRL/lpr Lupus-Prone Mouse Model. Int J Mol Sci. 2024;25. 10.3390/ijms251810080
- Muraoka S, Brodie WD, Mattichak MN, Gurrea-Rubio M, Ikari Y, et al. Targeting CD13/Aminopeptidase N as a Novel Therapeutic Approach for Scleroderma Fibrosis. Arthritis Rheumatol. 2025;77:80. 10.1002/art.42973
- Zoshima T, Baba T, Nakatani K, Nagata M, Mukaida N, et al. The CCL2-CCR2 axis determines whether glomerular endocapillary hypercellularity or wire-loop lesions develop through glomerular macrophage and neutrophil infiltration in lupus nephritis. J Pathol. 2024;264:174. 10.1002/path.6331
- Yin Y, Wu S. Ascorbic acid alleviates rheumatoid arthritis by inhibiting the production of autoantibodies. Cell Commun Signal. 2024;22:373. 10.1186/s12964-024-01756-x
- Wang T, Rathee A, Pemberton PA, Lood C. Exogenous serpin B1 restricts immune complex-mediated NET formation via inhibition of a chymotrypsin-like protease and enhances microbial phagocytosis. J Biol Chem. 2024;300:107533. 10.1016/j.jbc.2024.107533
